Washed up 完蛋screwed up
You go wash up.洗手
我真失败 我全搞砸了
I'm a failure. I'm all washed up
give up on sb. 介词搭配
If you give up on something or someone, you decide that you will never succeed in doing what you want to with them, and you stop trying. 对…表示绝望
He urged them not to give up on peace efforts.
他力劝他们不要对和平努力绝望。
We shouldn't give up on trying to find a diplomatic solution. 

⚠️give up对事情放弃，give up on sb，对人放弃（强烈的失望），give up on 有对....失望，绝望之意，而give up则没有这层含义。
另外，give up有动作倾向，give up on更倾向状态。
Give oneself up 自首
give up on this suit?放弃案子
能让我头脑清醒
They clarify the mind.sober